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thom, 3D is a 2-letter bibliographic abbreviation for "in the same place", then the first letters of "empty rubbish", all inside what Americans sometimes call a "john" (with one letter extra).

Defn is a sports term, "sweeper"

Thom, in 3D “sweeper” is the definition, think football. Also you need to know how authors reference a series of quotes - full source reference the first time an then a Latin abbreviation for “in the same place” thereafter. Then “starts” has a common meaning in such clues, and I’m sure you can think of some toilets!

3d definition sweeper
2 letter abbreviation for in the same place
+
2 single letter initial letters of words
all in three letter word for toilet

extra letter o.

Thank you! Will have a think. Not popping up in any of the usual brute-forcy venues but it can't be THAT obscure!

Got everything filled now except the bottom left vertical themed entry. I've got an idea, but can't quite parse it.

Similar to 1; here, 2 X (3) synonyms.

Thanks ginge. I was thinking of a different one, which didn't really work.

Can someone help me solve my missing piece. I am missing the final cell of the 3rd unclued across entry. I have all the rest, so am aware of what’s going on etc. I have scanned an exhaustive list and still nothing jumping out at me. Would appreciate a pointer. Thanks in advance

h982, If you look on the first 3 letters as a chemical formula, the rest will fall into place.

Thanks - I had that as MED-LAV elsewhere. Guess I need to re-look at that one…